Recently, a large number of colleagues in agricultural and chemical enterprises reported that Tricyclazole and its compound related suspension agent products, which were normally produced, had problems such as water evolution, pseudoplastic, paste and so on without changing the supplier of additives. The related solid preparation products also showed poor disintegration and low suspension rate. Tricyclazole is a conventional fungicide in rice field, which has a high market share. In view of the problems of this variety, we started from the source and adopted the formula solution with Qingyu characteristics to perfectly solve the related quality problems of the product.

　　1. Product problems

　　There are many problems in Tricyclazole technical preparation reported by colleagues in the industry. The typical sorting and summary are as follows.

　　It was found that Tricyclazole technical from different sources was quite different. Main reasons for the change of technical drug

　　1. Changes in raw materials of Tricyclazole technical drug: the original content of an intermediate in the upstream was 99%. The quality of the technical product has been very stable, and the adaptability of the technical drug to the dosage form is also very good. But now the content of intermediate is only 98%. Although the content of the technical drug synthesized does not change much, the scope of application of the preparation is small.

　　2. Changes in the synthesis process of Tricyclazole technical substance: the original Tricyclazole technical was washed and desalted for many times during the final purification. However, due to the current environmental protection pressure, the cleaning times may be greatly reduced, resulting in higher salt impurities in the technical material than in the past, which is also one of the change factors of the technical drug.

　　3. Changes in fineness of Tricyclazole technical ingredients: in the past, the technical materials had to go through the coarse powder. Now, due to environmental protection and cost factors, the crude technical ingredients are directly produced without crushing. These technical materials are large in size, and are not easy to air flow or grinding, which also has an impact.

　　2. Corresponding solutions

　　By comparing with the conventional formulation system for many rounds, Qingyu proposed a formulation system with sp-3275 + sp-3060 additives for suspension agent system of 40% Tricyclazole sc. the product has good stability, small particle size change and low heat storage viscosity.

　　The key quality indicators of the samples prepared according to the formula are as follows:

　　Through small-scale screening and large-scale production verification, aiming at 75% Tricyclazole DF and other dry suspension agent systems, Qingyu proposed a formulation system with sp-df2290 + sp-df2222 as the core adjuvant, which has good adaptability to the technical drug and no dead particles in large-scale production samples.

　　The key quality indicators of the samples prepared according to the formula are as follows:

　　Through small-scale screening and large-scale production verification, aiming at 75% Tricyclazole WDG and other water dispersible granule systems, Qingyu proposed a formulation system with sp-2818l + sp-2848w as the core adjuvant, which has good adaptability to the technical drug and no dead particles in large-scale production samples.

　　The key quality indicators of the samples prepared according to the formula are as follows:

　　Tricyclazole technical has changed a lot in recent years. The conventional formula can not adapt to this change. The product quality accidents occur frequently, and the technical colleagues in the circle are quite troubled. As a professional pesticide preparation processing technology and comprehensive service provider of reducing application and increasing efficiency, facing this problem is not only a challenge, but also an opportunity. Through the analysis of the problem products, the experiment shows that the application of Qingyu solution can effectively solve the formula adaptability of various formulations of Tricyclazole after the technical change, and it can be used safely through the large-scale production process verification.

　　Please contact Qingyu technical department for specific procesas and formula control parameters.